TDD Industry News and Views: Weekly Updates on Comings, Goings, and Other Happenings in Dermatology
Rion Aesthetics Rolls Out Refillable Packaging for Exosome Serums Rion Aesthetics’ refillable packaging is made from 50% post-consumer recycled (PCR) plastic with most elements 100% ready for recycling. “The redesigned bottles embody simplicity and functionality, aiming to add consumer-friendly innovation while minimizing the environmental footprint traditionally associated with skincare purchases,” says Alisa Lask, the CEO of Rion […]
COVID-19 Infection May Up Alopecia Risk
COVID-19 has been linked to new onsets or flares of systemic lupus erythematosus, inflammatory bowel disease, and rheumatoid arthritis, and a new nationwide study out of South Korea suggests it may also increase risk for onset, exacerbation, and recurrence of alopecia areata (AA). The researchers conducted a population-based cohort study to investigate the association between […]
Addressing These Five Factors Will Empower Your HS Patients to Seek Treatment
With the recent U.S. Food and Drug Administration approval of secukinumab (Cosentyx, Novartis) and a full pipeline, hidradenitis suppurativa (HS) is having a moment. Up until now, the TNF blocker adalimumab was the only approved treatment for moderate to severe HS in people 12 years and older. Now that there are more HS treatment options, Nicole Salame, MD, and […]
VYN201 Produces Positive Biomarker Changes in Vitiligo
VYN201 demonstrated a positive effect on key biomarkers relevant to nonsegmental vitiligo, according to new data from a Phase 1b Trial. VYNE Therapeutics Inc.’s VYN201 is a pan-bromodomain BET inhibitor designed to be locally administered to address diseases involving multiple, diverse inflammatory cell signaling pathways while providing low systemic exposure. BET inhibitors have the potential to […]
Exploring the Tumor Suppressor Activity of the PTEN Protein in Melanoma
Scientists have made significant progress in understanding the molecular mechanisms leading to melanoma development, but precisely how the PTEN protein regulated melanoma progression was unclear until now. In a new study published in Cancer Research, Moffitt Cancer Center researchers showed how the antitumor activity of PTEN suppresses the cancer-promoting activity of the FRA1 transcription factor through the AKT signaling pathway. Mutations […]
Uncovered: Bidirectional Link Between Autoimmune Disease and Perinatal Depression
Women with autoimmune disease are more likely to experience depression during pregnancy and after childbirth; conversely, women with a history of perinatal depression are at higher risk of developing autoimmune disease, according to a new study in Molecular Psychiatry. For the study, researchers used data from the Swedish Medical Birth Register and identified all women who had […]
Gene Editing May Allow C. acnes to Treat Acne, Other Conditions
Cutibacterium acnes can be engineered to produce molecules that treat acne, a new study suggests. For the study, which is published in Nature Biotechnology, researchers successfully edited the genome of Cutibacterium acnes to secrete and produce NGAL protein known to be a mediator of the acne drug, isotretinoin, which has been shown to reduce sebum by inducing the death […]
HS Pipeline Watch: Abbvie’s Lutikizumab Advances to Phase 3 in HS
Adults with moderate to severe hidradenitis suppurativa (HS) who had previously failed anti-TNF therapy showed higher response rates in Hidradenitis Suppurativa Clinical Response 50 (HiSCR) at week 16 when treated with lutikizumab (ABT-981) 300 mg every other week or 300 mg compared to patients who received placebo, according to results from a new Phase 2 study. […]
Study: DermTech’s Melanoma Test Can Rule Out the Cancer in Real-World Settings
DermTech, Inc.’s Melanoma Test (DMT) performed well in a real-world clinical setting, the Company reports. The test assesses pigmented skin lesions, moles or dark skin spots for melanoma. In particular, the PLA detects expression of the LINC00518 (LINC) and preferentially expressed antigen in melanoma (PRAME) genes using reverse transcription-polymerase chain reaction (RT-PCR). The Company introduced […]
Advances in Wound Healing: New High-Resolution Method May Help Analyze Skin Gene Expression After Burns
In findings that may help promote wound healing, scientists have developed a new high-resolution method to analyze skin gene expression post burns. The findings were published in the Journal of Burn Care & Research: official publication of the American Burn Association. Studying the timeline of gene activity after a burn is crucial for deciding optimal time for […]