Off-label Pearl: Chondrodermatitis nodularis helicis
By Ted Rosen, MD, FAAD, Editor-in-Chief Chondrodermatitis nodularis helicis is a painful degenerative condition affecting the ear. Surgical removal or intralesional steroid injections are standard therapeutic interventions. A small clinical trial involved the use of topical nitroglycerin patches, assuming that part of the pathogenesis includes localized ischemia. Self-adhesive nitroglycerin patches (at the concentration of 5mg/24 […]
Simvastatin for venuous ulcers
By Ted Rosen,MD,FADD,Editor-in-Chief The statin class of medications has salutatory, ancillary benefits, which may facilitate cutaneous wound healing. These include anti-inflammatory effects, enhanced epithelialization, and increased neoangiogenesis. Thus, the use of statins (such as atorvastatin and simvastatin) may be considered in situations where cutaneous healing is expected to be delayed or difficult. For example, 40mg […]
Off-Label Pearl: Elastosis Perforans Serpiginosa
Off-label Pearl
By Ted Rosen, MD, FAAD, Editor-in-Chief Literature Lessons HIDRADENITIS SUPPURATIVA A case of flaring HS during PREGNANCY was successfully managed using certolizumab pegol 400 mg SC every week. Certolizumab pegol does not cross the placental barrier, and is thus considered safe for use during pregnancy. TO READ MORE: Wohlmuth-Wieser I, Alhusayen R. Treatment of hidradenitis […]
Dermatologic applications of Polypodium leucotomos (PLE)
By Ted Rosen, MD, FAAD, Editor-in-Chief The mainstay of treatment for polymorphic light eruption includes the use of sunscreen and ultraviolet light avoidance, along with topical corticosteroids. However, these maneuvers may be difficult for some who work outdoors or spend extended recreational time outdoors. Oral administration of standardized Polypodium leucotomos extract (PLE) may vastly reduce […]